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- Title
ZABURZENIA WYCHWYTOWEJ FUNKCJI NEREK W BADANIU SPECT U PACJENTÓW CHORYCH NA CUKRZYCĘ TYPU 1 - DONIESIENIE WSTĘPNE.
- Authors
Szadkowska, Agnieszka; Pietrzak-Stelmasiak, Ewa; Surma, Marian J.; Frieske, Izabela; Kuśmierek, Jacek; Bodalski, Jerzy
- Abstract
Introduction: Nephropathy belongs to the most serious chronic complications of type 1 diabetes mellitus. The aim of the study was to estimate the prevalence of renal uptake dysfunction in type 1 diabetic patients in renal SPECT examination and its relationship with microangiopathy and laboratory markers of atherosclerosis. Materials and methods: 37 patients at the age 21 to 34 years and duration of diabetes above 10 years were included into the study. In patients SPECT examination was performed. Creatinine, lipids and CRP concentration in plasma and albuminuria, ERPF were measured. The presence of retinopathy and arterial hypertension was evaluated. Results: The local uptake renal dysfunction was found in one kidney in 22 patients (59.5%) (mainly one focus of worsen uptake), and in both kidneys - in 4 individuals (10.8%). In 11 patients (29.7%) no disturbances was found. The prevalence of microalbuminuria (p=0.005), retinopathy (p=0.001) and arterial hypertension (p=0.007) increased in parallel to the intensification of renal uptake dysfunction. In addition laboratory markers of renal suficiency deteriorated: creatinine concentration (p<0.001) and ERPF (p<0.001). There were no differences between patients with and without renal uptake dysfunction in lipids and CRP plasma concentration. Conclusion: Local renal uptake dysfunction are observed in significant percentage of type 1 diabetic patients. There is relationship between the prevalence of renal uptake dysfunction and microangiopathy, but not with laboratory markers of atherosclerosis. Further examination are needed to confirm these results.
- Subjects
DIABETES; KIDNEY diseases; PEOPLE with diabetes; ATHEROSCLEROSIS; CREATINE; LIPIDS; BIOMOLECULES; ARTERIOSCLEROSIS; AMINO acids
- Publication
Przeglad Pediatryczny, 2009, Vol 39, Issue 1, p19
- ISSN
0137-723X
- Publication type
Article