We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Nutritional strategies cause memory damage and alter biochemical parameters without causing neuroinflammation.
- Authors
de Souza, Keila Rufatto; Engel, Nicole Alessandra; Soares, Hevylin Jacinto; Bressan, Catarina Barbosa Chaves; Dela Vedova, Larissa Marques; da Silva, Larissa Espindola; Mendes, Talita Farias; da Silva, Mariella Reinol; de Oliveira, Mariana Pacheco; Goulart, Amanda Indalecio; Córneo, Emily; de Medeiros Borges, Heloísa; Michels, Monique; Bittencourt, João Vitor Silvano; de Roch Casagrande, Laura; Ferreira, Gabriela Kozuchovski; Petronilho, Fabricia Cardoso; Dal-Pizzol, Felipe; Silveira, Paulo Cesar Lock; de Bitencourt, Rafael Mariano
- Abstract
Obesity results from an energy imbalance and has been considered an epidemic due to its increasing rates worldwide. It is classified as a low-grade chronic inflammatory disease and has associated comorbidities. Different nutritional strategies are used for the purpose of weight loss, highlighting low-carbohydrate (LC) diets, ketogenic diets, and intermittent fasting (IF). These strategies can lead to metabolic and behavioral changes as they stimulate different biochemical pathways. Therefore, this study evaluated memory, energy metabolism, neuroinflammation, oxidative stress, and antioxidant defense parameters in mice subjected to an LC diet, ketogenic diet (KD), or IF. Eighty male Swiss mice, 60 days old, were divided into 4 groups: control, LC, KD, or IF. Body weight was measured weekly, and food intake every 48 h. After 15 days of nutritional interventions, the animals were subjected to the behavioral object recognition test and subsequently euthanized. Then, visceral fat was removed and weighed, and the brain was isolated for inflammatory and biochemical analysis. We concluded from this study that the LC and KD strategies could damage memory, IF improves the production of adenosine triphosphate (ATP), and the LC, KD, and IF strategies do not lead to neuroinflammatory damage but present damage at the level of oxidative stress.
- Subjects
INTERMITTENT fasting; KETOGENIC diet; NEUROINFLAMMATION; ADENOSINE triphosphate; LABORATORY mice; IMMOBILIZATION stress
- Publication
Metabolic Brain Disease, 2024, Vol 39, Issue 4, p635
- ISSN
0885-7490
- Publication type
Article
- DOI
10.1007/s11011-023-01311-6