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- Title
Cardiac magnetic resonance and electroanatomical mapping of acute and chronic atrial ablation injury: a histological validation study.
- Authors
Harrison, James L.; Jensen, Henrik K.; Peel, Sarah A.; Chiribiri, Amedeo; Grøndal, Anne K.; Bloch, Lars Ø.; Pedersen, Steen F.; Bentzon, Jacob F.; Kolbitsch, Christoph; Karim, Rashed; Williams, Steven E.; Linton, Nick W.; Rhode, Kawal S.; Gill, Jaswinder; Cooklin, Michael; Rinaldi, C.A.; Wright, Matthew; Kim, Won Y.; Schaeffter, Tobias; Razavi, Reza S.
- Abstract
Aims To provide a comprehensive histopathological validation of cardiac magnetic resonance (CMR) and endocardial voltage mapping of acute and chronic atrial ablation injury. Methods and results 16 pigs underwent pre-ablation T2-weighted (T2W) and late gadolinium enhancement (LGE) CMR and high-density voltage mapping of the right atrium (RA) and both were repeated after intercaval linear radiofrequency ablation. Eight pigs were sacrificed following the procedure for pathological examination. A further eight pigs were recovered for 8 weeks, before chronic CMR, repeat RA voltage mapping and pathological examination. Signal intensity (SI) thresholds from 0 to 15 SD above a reference SI were used to segment the RA in CMR images and segmentations compared with real lesion volumes. Conclusion This study presents the first histopathological validation of CMR and endocardial voltage mapping to define acute and chronic atrial ablation injury, including SI thresholds that best match histological lesion volumes. An understanding of these thresholds may allow a more informed assessment of the underlying atrial substrate immediately after ablation and before repeat catheter ablation for atrial arrhythmias.
- Publication
European Heart Journal, 2014, Vol 35, Issue 22, p1486
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/eht560