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- Title
DNA-hydrolysing activity of IgG antibodies from the sera of patients with diseases caused by different bacterial infections.
- Authors
Parkhomenko, Taisiya A.; Odintsova, Elena S.; Buneva, Valentina N.; Kunder, Elena V.; Zhyltsov, Ivan V.; Senkovich, Sergey A.; Generalov, Igor I.; Nevinsky, Georgy A.
- Abstract
DNase autoantibodies (Abs) can be found in the blood of patients with several autoimmune diseases, while the blood of healthy donors or patients with diseases with insignificant disturbances of the immune status does not contain the DNase Abs. Here we have analysed for the first time the DNase activity in the patients with diseases caused by several bacterial infections. Several rigid criteria have been applied to show that the DNase activity is an intrinsic property of IgGs from the sera of patients with bacterial diseases but not from healthy donors. The relative activity of IgGs has been shown to vary extensively between the diseases analysed and from patient to patient, but most of the preparations had detectable levels of the DNase activity. On average, the catalytic activities were significantly lower than in patients with autoimmune pathologies and increased in the following order: streptococcal infection (erysipelas) < urogenital chlamydiosis associated with arthritis (Reiter’s disease) < meningococcal meningitis < shigellosis < suppurative surgical infections caused by Staphylococcus aureus < suppurative surgical infections caused by epidermal staphylococci < urogenital ureaplasmosis associated with reactive arthritis. While intact IgGs possessed this catalytic activity, separated light chains of polyclonal Abs appeared to be even more active in the hydrolysis of DNA.
- Subjects
ANTI-immunoglobulin autoantibodies; BACTERIAL diseases; AUTOIMMUNE diseases; PREVENTIVE medicine; INFECTIOUS arthritis; PROTEIN hydrolysates; COMMUNICABLE diseases; SHIGELLOSIS
- Publication
Journal of Cellular & Molecular Medicine, 2009, Vol 13, Issue 9a, p2875
- ISSN
1582-1838
- Publication type
Article
- DOI
10.1111/j.1582-4934.2008.00441.x