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- Title
Randomized, dose-finding trial of ghrelin treatment for chronic respiratory failure.
- Authors
Miki, Keisuke; Maekura, Ryoji; Nakazato, Masamitsu; Matsumoto, Nobuhiro; Kitada, Seigo; Miki, Mari; Yoshimura, Kenji; Mori, Masahide; Kangawa, Kenji
- Abstract
Objectives Ghrelin, a growth hormone-releasing peptide, has shown efficacy in chronic obstructive pulmonary disease (COPD) patients in previous trials. This study was designed to evaluate the effective dose of ghrelin in chronic respiratory failure patients. Methods In this randomized, double-blind, dose-finding, single-center study, 18 patients, including 16 with COPD, were randomly assigned to receive pulmonary rehabilitation (PR) with intravenous ghrelin at 1 μg/kg or 2 μg/kg, twice daily for 3 weeks. The primary outcome was the change in peak oxygen uptake (
- Subjects
GHRELIN; CHRONIC disease treatment; RESPIRATORY insufficiency treatment; LUNG diseases; AEROBIC capacity; PATIENTS; THERAPEUTICS
- Publication
Clinical Respiratory Journal, 2017, Vol 11, Issue 4, p496
- ISSN
1752-6981
- Publication type
Article
- DOI
10.1111/crj.12364