We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Blocking of angiotensin II is more than blocking of transforming growth factor-beta.
- Authors
Daniel C
- Abstract
Fibrosis is a common feature of chronic kidney diseases that is mediated by matrix-producing myofibroblasts. One potential origin of myofibroblasts is epithelial-mesenchymal transition (EMT) of tubuloepithelial cells. Transforming growth factor-beta (TGF-beta) is a key factor inducing EMT. Carvajal et al. demonstrate that angiotensin II induces EMT by classical stimulation of TGF-beta and also by a TGF-beta-independent pathway, both signaling via Smad molecules. Therefore, blockade of angiotensin II is more than lowering of blood pressure and inhibition of TGF-beta stimulation.
- Publication
Kidney International, 2008, Vol 74, Issue 5, p551
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1038/ki.2008.290