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- Title
Proteinuria in diabetic kidney disease: A mechanistic viewpoint.
- Authors
Jefferson, J. A.; Shankland, S. J.; Pichler, R. H.
- Abstract
Proteinuria is the hallmark of diabetic kidney disease (DKD) and is an independent risk factor for both renal disease progression, and cardiovascular disease. Although the characteristic pathological changes in DKD include thickening of the glomerular basement membrane and mesangial expansion, these changes per se do not readily explain how patients develop proteinuria. Recent advances in podocyte and glomerular endothelial cell biology have shifted our focus to also include these cells of the glomerular filtration barrier in the development of proteinuria in DKD. This review describes the pathophysiological mechanisms at a cellular level which explain why patients with DKD develop proteinuria.Kidney International (2008) 74, 22–36; doi:10.1038/ki.2008.128; published online 16 April 2008
- Subjects
PROTEINURIA; KIDNEY diseases; URINALYSIS; CARDIOVASCULAR diseases; BIOLOGICAL membranes; ACUTE kidney failure
- Publication
Kidney International, 2008, Vol 74, Issue 1, p22
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2008.128