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- Title
Vascular complications are associated with poor outcome in community-acquired pneumonia.
- Authors
Mandal, P.; Chalmers, J. D.; Choudhury, G.; Akram, A. R.; Hill, A. T.
- Abstract
Background: Recognition of cardiovascular risk factors is important for primary and secondary prevention strategies. Recent evidence has linked lower respiratory tract infections with the development of acute myocardial infarction.Aim: The aim of this study was to determine the frequency of cardiovascular and cerebrovascular events and the clinical outcomes, during hospitalization for community-acquired pneumonia (CAP).Design: We performed a retrospective study of 4408 patients with CAP presenting to five hospitals over a 2-year period. Clinical information, co-morbidities, cardiovascular events and 90-day mortality were collected from review of medical case notes. The relationship between cardiovascular events and outcomes were analysed using multivariable logistic regression.Results: From a total of 4408 patients, 2.2% developed stroke, 5% acute coronary syndrome or myocardial infarction and 9.3% new onset atrial fibrillation. These were associated with increased 90-day mortality [odds ratio (OR), 1.49 95% CI 1.18–1.87, P = 0.0006].Vascular events were independently associated with increased length of hospital stay—median 12 days (IQR 5–22), compared to patients with no vascular events 8 days (IQR 3–17 days, P < 0.0001).Conclusions: Cardiovascular and cerebrovascular events are common during hospitalization for CAP and are associated with increased 90-day mortality.
- Subjects
CARDIOVASCULAR diseases risk factors; RESPIRATORY infections; MYOCARDIAL infarction; COMMUNITY-acquired pneumonia; CEREBROVASCULAR disease; COMORBIDITY; CARDIOVASCULAR disease related mortality; LOGISTIC regression analysis
- Publication
QJM: An International Journal of Medicine, 2011, Vol 104, Issue 6, p489
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcq247