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- Title
Improvement of factor VII clotting activity following long-term NCPAP treatment in obstructive sleep apnoea syndrome.
- Authors
Chin, K; Kita, H; Noguchi, T; Otsuka, N; Tsuboi, T; Nakamura, T; Shimizu, K; Mishima, M; Ohi, M
- Abstract
Obstructive sleep apnoea syndrome (OSAS) is a very common disorder. Patients with OSAS are at an increased risk for cardiovascular events. It has also been reported that a 25% rise in factor VII clotting activity (FVIIc) is associated with a 55% increase in ischaemic heart disease death during the first 5 years. We examined the effects of nasal continuous positive airway pressure (NCPAP) treatment on FVIIc in patients with OSAS. FVIIc was investigated prospectively in 15 patients with OSAS before (mean ± SEM apnoea and hypopnoea index (AHI) 61.5 ± 4.2 and after (AHI 3.0 ± 0.9) NCPAP treatment for immediate relief, at 1 month after treatment and at over 6 months. FVIIc levels gradually decreased after NCPAP treatment. After 6 months of NCPAP treatment, FVIIc levels had decreased significantly (before 141.1 ± 11.7% vs. after 6 months 110.7 ± 6.2%; p<0.01). Six of the seven patients whose FVIIc levels were over 140% before the NCPAP treatment had FVIIc levels below 130% after 6 months or 1 year of NCPAP treatment. This decrease in FVIIc after long-term NCPAP treatment could improve mortality in OSAS patients. If patients, especially obese ones, present with high FVIIc of unknown origin, it would be prudent to check for OSAS.
- Publication
QJM: An International Journal of Medicine, 1998, Vol 91, Issue 9, p627
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/91.9.627