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- Title
Generation of antibodies specific for β-amyloid by vaccination of patients with Alzheimer disease.
- Authors
Hock, Christoph; Konietzko, Uwe; Papassotiropoulos, Andreas; Wollmer, Axel; Streffer, Johannes; von Rotz, Ruth C.; Davey, Gabriela; Moritz, Eva; Nitsch, Roger M.
- Abstract
To characterize antibodies produced in humans in response to Aβ[sub 42] vaccination, we carried out immunohistochemical examinations of the brains of both transgenic mice and human patients with β-amyloid pathology. We collected sera from patients with Alzheimer disease who received a primary injection of pre-aggregated Aβ[sub 42] followed by one booster injection in a placebo-controlled study. Antibodies in immune sera recognized β-amyloid plaques, diffuse Aβ deposits and vascular β-amyloid in brain blood vessels. The antibodies did not cross-react with native fulllength β-amyloid precursor protein or its physiological derivatives, including soluble Aβ[sub 42]. These findings indicate that vaccination of AD patients with Aβ[sub 42] induces antibodies that have a high degree of selectivity for the pathogenic target structures. Whether vaccination to produce antibodies against β-amyloid will halt the cognitive decline in AD will depend upon clinical assessments over time.
- Subjects
IMMUNOGLOBULINS; AMYLOID beta-protein; ALZHEIMER'S patients
- Publication
Nature Medicine, 2002, Vol 8, Issue 11, p1270
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm783