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- Title
Synthesis and Activity Evaluation of 2-(1-naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles.
- Authors
KUMARASWAMY, M. N.; CHANDRASHEKHAR, C.; SHIVAKUMAR, H.; MATHIAS, D. A. PRATHIMA; MAHADEVAN, K. M.; VAIDYA, V. P.
- Abstract
Ethyl naphtho[2,1-b]furan-2-carboxylate (2) on reaction with hydrazine hydrate in presence of acid catalyst in ethanol medium affords naphtho[2,1-b]furan-2-carbohydrazide (3). The reaction of substituted acetophenones (4a-c) with aromatic aldehydes (5a-e) produces chalcones (6a-o) via the Claisen condensation. The reaction of naphtho[2,1-b]furan-2-carbohydrazide (3) with chalcones (6a-6o) in presence of acetic acid as catalyst in dioxane produces 1-(naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles (7a-o). The structures of newly synthesized compounds have been established by elemental analysis and spectral studies. The compounds 7a-o have been evaluated for their antimicrobial activity and some selected compounds evaluated for antiinflammatory, analgesic, anthelmintic, diuretic and antipyretic activities.
- Subjects
PYRAZOLES; HYDRATES; COMPLEX compounds; CHEMICAL reactions; ANTI-infective agents; PHARMACOLOGY
- Publication
Indian Journal of Pharmaceutical Sciences, 2008, Vol 70, Issue 6, p715
- ISSN
0250-474X
- Publication type
Article