We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Adverse pregnancy outcome in women with mild glucose intolerance: is there a clinically meaningful threshold value for glucose?
- Authors
Jensen, Dorte M.; Korsholm, Lars; Ovesen, Per; Beck-Nielsen, Henning; Mølsted-Pedersen, Lars; Damm, Peter
- Abstract
Background. The diagnostic criteria of gestational diabetes mellitus (GDM) have been based on the risk of future maternal diabetes rather than the short-term risk of mother and infant. Our aim was to illustrate the relation between various adverse pregnancy outcomes and maternal glucose levels in women with mild glucose intolerance using a graphical approach. Methods. Observational study of 2,885 pregnant women examined with a 2-h, 75-g oral glucose tolerance test (OGTT) based on risk indicators. Only women with 2-h capillary blood glucose <9.0 mmol/l were included, as women with 2-h values ≥9.0 mmol/l were treated for GDM. Empirical frequencies of adverse outcomes were related to 2-h values by linear and quadratic logistic models. Adjustments for well-known confounders were performed by a multiple logistic model. Results. Linear trends were demonstrated for the outcomes: shoulder dystocia, caesarean section rate (univariate analysis only), spontaneous preterm delivery, and macrosomia (large-for-gestational age infants). None of the outcomes deviated significantly from linearity. No significant trend was found for hypertension or neonatal hypoglycaemia and jaundice. Conclusions. A gradually increasing risk for a number of adverse pregnancy outcomes was found with increasing glucose levels. No obvious threshold value for GDM was demonstrated for 2-h values up to 9.0 mmol/l.
- Subjects
PREGNANCY; DIAGNOSIS of diabetes; GESTATIONAL age; BLOOD testing; GLUCOSE
- Publication
Acta Obstetricia et Gynecologica Scandinavica, 2008, Vol 87, Issue 1, p59
- ISSN
0001-6349
- Publication type
Article
- DOI
10.1080/00016340701823975