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- Title
Efficacy of antibiotic prophylaxis prior to tympanoplasty for contaminated cholesteatoma.
- Authors
Pierce, Nathan E.; Antonelli, Patrick J.
- Abstract
<bold>Objectives: </bold>To evaluate the efficacy of combined antistaphylococcal and antipseudomonal preoperative antibiotics for preventing surgical site infections following tympanoplasty and mastoidectomy with contaminated cholesteatoma.<bold>Study Design: </bold>Retrospective chart review.<bold>Methods: </bold>Medical records of patients who underwent tympanoplasty ± mastoidectomy for cholesteatoma were reviewed. Only cases considered to have contaminated or dirty surgical fields were included. The primary outcome measure was occurrence of postoperative surgical site infections, perichondritis, pinna abscess, periotic cellulitis, or periotic abscess requiring systemic antibiotic therapy or surgical intervention.<bold>Results: </bold>The charts of 326 patients who underwent tympanoplasty ± mastoidectomy were reviewed. Of those, 195 met inclusion criteria. Preoperative antibiotics included clindamycin and ceftazidime or gentamicin. Patients treated with no perioperative antibiotics had a surgical site infection rate of 11%, and those treated with perioperative antibiotics had a rate of 1% (P = 0.02).<bold>Conclusion: </bold>Administration of preoperative antibiotics to cover staphylococcal and pseudomonal species may prevent surgical site infections with tympanoplasty ± mastoidectomy for contaminated cholesteatoma.<bold>Level Of Evidence: </bold>4. Laryngoscope, 126:2363-2366, 2016.
- Subjects
ANTIBIOTIC prophylaxis; TYMPANOPLASTY; CHOLESTEATOMA; SURGICAL site; INFECTION prevention; ANTIBIOTICS; STAPHYLOCOCCAL disease prevention; CLINDAMYCIN; GENTAMICIN; PSEUDOMONAS diseases; STAPHYLOCOCCAL diseases; SURGICAL site infections; VANCOMYCIN; TREATMENT effectiveness; RETROSPECTIVE studies; CEFTAZIDIME; PREVENTION
- Publication
Laryngoscope, 2016, Vol 126, Issue 10, p2363
- ISSN
0023-852X
- Publication type
journal article
- DOI
10.1002/lary.26192