We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prevalence of musculoskeletal pain and statin use.
- Authors
Buettner, Catherine; Davis, Roger B.; Leveille, Suzanne G.; Mittleman, Murray A.; Mukamal, Kenneth J.
- Abstract
<bold>Background: </bold>Muscle effects are the most common reported adverse effects of 3-hydroxy-3-methylglutaryl coenzyme A inhibitors (statins). However, in placebo-controlled trials the incidence of muscle pain is most often similar for placebo and active control groups.<bold>Objective: </bold>We sought to evaluate whether statin use was associated with a higher prevalence of musculoskeletal pain in a nationally representative sample.<bold>Methods: </bold>Cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. Participants were 3,580 adults > or =40 years without arthritis who were interviewed at home and examined in a mobile examination center. Participants were asked about sociodemographic characteristics, health conditions, medication use, and musculoskeletal pain. Height, weight, blood pressure, ankle brachial index, and cholesterol were measured.<bold>Measurements and Main Results: </bold>Prevalence and adjusted odds ratios (OR) of any musculoskeletal pain and musculoskeletal pain in 4 different anatomical regions (neck/upper back, upper extremities, lower back, and lower extremities) by statin use during the last 30 days. Among statin users (n = 402), 22.0% (95%CI 18.0-26.7%) reported musculoskeletal pain in at least 1 anatomical region during the last 30 days, compared with 16.7% (95%CI 15.1-18.4%) of those who did not use a statin. Compared to persons who did not use statins, those who used statins had multivariable-adjusted odds ratios (95%CI; p value) of 1.50 (1.07-2.11; p = .01) for any musculoskeletal pain, 1.59 (1.04-2.44, p = .03) for lower back pain, and 1.50 (1.02-2.22, p = .03) for lower extremity pain.<bold>Conclusion: </bold>Musculoskeletal pain is common in adults > or =40 years without arthritis. In this nationally representative sample, statin users were significantly more likely to report musculoskeletal pain.
- Subjects
UNITED States; STATINS (Cardiovascular agents); MUSCULOSKELETAL system diseases; PLACEBOS; CONTROL groups; MYALGIA; ANTILIPEMIC agents; CROSS-sectional method; SURVEYS; CHI-squared test; DISEASE prevalence; COMMERCIAL product evaluation; LOGISTIC regression analysis
- Publication
JGIM: Journal of General Internal Medicine, 2008, Vol 23, Issue 8, p1182
- ISSN
0884-8734
- Publication type
journal article
- DOI
10.1007/s11606-008-0636-7