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- Title
CHEMICAL COMPOSITION, CHARACTERIZATION OF ANTHOCYANINS AND ANTIOXIDANT POTENTIAL OF EUTERPE EDULIS FRUITS: APPLICABILITY ON GENETIC DYSLIPIDEMIA AND HEPATIC STEATOSIS IN MICE.
- Authors
Cardoso, Luciana Marques; Novaes, Rômulo Dias; de Castro, Cynthia Aparecida; Novello, Alexandre Azevedo; Gonçalves, Reggiani Vilela; Ricci-Silva, Maria Esther; de Oliveira Ramos, Humberto Josué; do Carmo Gouveia Peluzio, Maria; Viana Leite, João Paulo; Marques Cardoso, Luciana; Dias Novaes, Rômulo; Aparecida de Castro, Cynthia; Azevedo Novello, Alexandre; Vilela Gonçalves, Reggiani; Gouveia Peluzio, Maria do Carmo
- Abstract
<bold>Unlabelled: </bold>The significance of polyphenol intake for the prevention of chronic diseases is controversial.<bold>Objective: </bold>this study investigated the chemical composition and antioxidant potential of an anthocyanin-rich extract from Euterpe edulis fruits (LPEF) and its effects on liver steatosis in dyslipidemic apoE-/- knockout mice.<bold>Materials and Methods: </bold>mice were divided into G1 (C57BL/6) standard diet; G2 (apoE-/-) standard diet, G3 (apoE-/-) 2% LPEF, G4 (apoE-/-) 6% LPEF, G5 (apoE-/-) 10% LPEF, G6 (apoE-/-) 2% α-tocopherol acetate. After 75 days of treatment, the animals were euthanized. The LPEF contained a high level of monomeric anthocyanins (301.4 mg/100g) and marked antioxidant activity.<bold>Results: </bold>Catalase activity was reduced in G3, G4, G5 and G6 compared to G2. Superoxide dismutase was reduced only in G4. The animals in G4, G5, and G6 showed low HDL and triglycerides levels compared to G2. The proportion of lipid droplets in liver tissue was reduced in G4 and G5 compared to G2, G3, and G6.<bold>Conclusion: </bold>The results indicated that E. edulis pulp is rich in anthocyanins and the LPEF dietary consumption can reduce the severity of liver steatosis in apoE-/- mice, an effect that is potentially mediated by the antioxidant activity of this extract and modulation of triglyceride serum levels.
- Subjects
EUTERPE edulis; ANTHOCYANINS; ANTIOXIDANTS; DYSLIPIDEMIA; FATTY liver
- Publication
Nutrición Hospitalaria, 2015, Vol 32, Issue 2, p702
- ISSN
0212-1611
- Publication type
journal article
- DOI
10.3305/nh.2015.32.2.8885