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- Title
Morphine acts in vitro to directly prime nociceptors.
- Authors
Khomula, Eugen V.; Levine, Jon D.
- Abstract
Hyperalgesic priming is a preclinical model of the transition from acute to chronic pain characterized by a leftward shift in the dose-response curve for and marked prolongation of prostaglandin E2 (PGE2)-induced mechanical hyperalgesia, in vivo. In vitro, priming in nociceptors is characterized by a leftward shift in the concentration dependence for PGE2-induced nociceptor sensitization. In the present in vitro study we tested the hypothesis that a mu-opioid receptor (MOR) agonist opioid analgesic, morphine, can produce priming by its direct action on nociceptors. We report that treatment of nociceptors with morphine, in vitro, produces a leftward shift in the concentration dependence for PGE2-induced nociceptor sensitization. Our findings support the suggestion that opioids act directly on nociceptors to induce priming.
- Subjects
NOCICEPTORS; MORPHINE; DIRECT action; HYPERALGESIA; CHRONIC pain
- Publication
Molecular Pain, 2024, p1
- ISSN
1744-8069
- Publication type
Article
- DOI
10.1177/17448069241260348