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- Title
Early changes in renal resistive index and mortality in diabetic and nondiabetic kidney transplant recipients: a cohort study.
- Authors
de Freminville, Jean-Baptiste; Vernier, Louis-Marie; Roumy, Jérome; Patat, Frédéric; Gatault, Philippe; Sautenet, Bénédicte; Barbet, Christelle; Longuet, Hélène; Merieau, Elodie; Buchler, Matthias; Halimi, Jean-Michel
- Abstract
<bold>Background: </bold>Renal resistive index (RI) predicts mortality in renal transplant recipients (RTR). However, its predictive value may be different according to the time of measurement. We analysed RI changes between 1 month and 3 months after transplantation and its predictive value for death with a functioning graft (DWFG).<bold>Methods: </bold>We conducted a retrospective study in 1685 RTR between 1985 and 2017. The long-term predictive value of changes in RI value from 1 month to 3 months was assessed in diabetic and non-diabetic RTR.<bold>Results: </bold>Best survival was observed in RTR with RI < 0.70 both at 1 and 3 months, and the worst survival was found in RTR with RI ≥ 0.70 both at 1 and 3 months (HR = 3.77, [2.71-5.24], p < 0.001). The risk of DWFG was intermediate when RI was < 0.70 at 1 month and ≥ 0.70 at 3 months (HR = 2.15 [1.29-3.60], p = 0.003) and when RI was ≥0.70 at 1 month and < 0.70 at 3 months (HR = 1.90 [1.20-3.03], p = 0.006). In diabetic RTR, RI was significantly associated with an increased risk of death only in those with RI < 0.70 at 1 month and ≥ 0.70 at 3 months (HR = 4.69 [1.07-20.52], p = 0.040). RI considered as a continuous variable at 1 and 3 months was significantly associated with the risk of DWFG in nondiabetic but not in diabetic RTR.<bold>Conclusion: </bold>RI changes overtime and this impacts differently diabetic and nondiabetic RTR. RI short-term changes have a strong prognosis value and refines the risk of DWFG associated with RI.
- Subjects
KIDNEY transplantation; COHORT analysis; MORTALITY; TIME measurements
- Publication
BMC Nephrology, 2021, Vol 22, Issue 1, p1
- ISSN
1471-2369
- Publication type
journal article
- DOI
10.1186/s12882-021-02263-8