We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
MICRODOSIMETRIC APPLICATIONS IN PROTON AND HEAVY ION THERAPY USING SILICON MICRODOSIMETERS.
- Authors
Chartier, L; Tran, L T; Bolst, D; Guatelli, S; Pogossov, A; Prokopovich, D A; Reinhard, M I; Perevertaylo, V; Anderson, S; Beltran, C
- Abstract
Using the CMRP ‘bridge' μ + probe, microdosimetric measurements were undertaken out-of-field using a therapeutic scanning proton pencil beam and in-field using a 12C ion therapy field. These measurements were undertaken at Mayo Clinic, Rochester, USA and at HIMAC, Chiba, Japan, respectively. For a typical proton field used in the treatment of deep-seated tumors, we observed dose-equivalent values ranging from 0.62 to 0.99 mSv/Gy at locations downstream of the distal edge. Lateral measurements at depths close to the entrance and along the SOBP plateau were found to reach maximum values of 3.1 mSv/Gy and 5.3 mSv/Gy at 10 mm from the field edge, respectively, and decreased to ~0.04 mSv/Gy 120 mm from the field edge. The ability to measure the dose-equivalent with high spatial resolution is particularly relevant to healthy tissue dose calculations in hadron therapy treatments. We have also shown qualitatively and quantitively the effects critical organ motion would have in treatment using microdosimetric spectra. Large differences in spectra and RBE10 were observed for treatments where miscalculations of 12C ion range would result in critical structures being irradiated, showing the importance of motion management.
- Subjects
RADIATION dosimetry; PROTON therapy; HEAVY ion accelerators; SILICON; RADIATION doses; NEUTRON source spectra
- Publication
Radiation Protection Dosimetry, 2018, Vol 180, Issue 1-4, p365
- ISSN
0144-8420
- Publication type
Article
- DOI
10.1093/rpd/ncx226