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- Title
Vitamin E dependent microRNA regulation in rat liver
- Authors
Gaedicke, Sonja; Zhang, Xiangnan; Schmelzer, Constance; Lou, Yijia; Doering, Frank; Frank, Jan; Rimbach, Gerald
- Abstract
Abstract: Dietary vitamin E (VE) is known to regulate gene expression by altering mRNA concentrations. Recently, microRNA (miRNA) have been discovered as a means of posttranscriptional gene regulation. Since the effect of VE on miRNA regulation is unknown, we fed rats for 6 months diets deficient or sufficient in VE and determined hepatic concentrations of miRNA involved in processes previously associated with VE (lipid metabolism, miRNA-122a; cancer and inflammation, miRNA-125b). VE-deficiency resulted in reduced concentrations of miRNA-122a and miRNA-125b. The findings of the present study demonstrate that differences in dietary VE may affect hepatic miRNA concentrations in vivo.
- Subjects
VITAMIN E; RNA; GENE expression; GENETIC regulation
- Publication
FEBS Letters, 2008, Vol 582, Issue 23/24, p3542
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.09.032