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- Title
Anti-cytokine autoantibodies are ubiquitous in healthy individuals
- Authors
Watanabe, Masato; Uchida, Kanji; Nakagaki, Kazuhide; Kanazawa, Hiroko; Trapnell, Bruce C.; Hoshino, Yoshihiko; Kagamu, Hiroshi; Yoshizawa, Hirohisa; Keicho, Naoto; Goto, Hajime; Nakata, Koh
- Abstract
Abstract: Anti-cytokine autoantibodies in healthy individuals have been widely reported but the occurrence is variable and inconstant. We hypothesized that cytokine-binding in vivo may explain their variable and infrequent detection. Therefore, we focused on the detection of the cytokine-autoantibody complexes and found that anti-cytokine autoantibody to IL-2, IL-8, tumor necrosis factor-α, vascular endothelial growth factor and granulocyte-colony stimulating factor were present in all 15 individuals evaluated, while those to IL-3, osteopontin and macrophage-colony stimulating factor were not detected in anyone. Autoantibodies against IL-4, IL-6, IL-10, and interferon-gamma were variously detected. Thus, we discovered that anti-cytokine autoantibodies to multiple cytokines are ubiquitous in healthy individuals.
- Subjects
GRANULOCYTE-macrophage colony-stimulating factor; CELLULAR immunity; GROWTH factors; GLYCOPROTEINS
- Publication
FEBS Letters, 2007, Vol 581, Issue 10, p2017
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.04.029