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- Title
HCMV infection attenuates hydrogen peroxide induced endothelial apoptosis – involvement of ERK pathway
- Authors
Wang, Jing; Shen, Ying H.; Utama, Budi; Wang, Jian; LeMaire, Scott A.; Coselli, Joseph S.; Vercellotti, Greg M.; Wang, Xing Li
- Abstract
Abstract: Human cytomegalovirus (HCMV) exerts anti-apoptotic effect during early stage of infection, which provides HCMV time for propagation. We investigated pathways mediating the resistance to H2O2-induced cell death – a self-defense mechanism to remove infected cells. We found that human aortic endothelial cells (HAECs) infected with VHL/E strain of HCMV during first 3 days were resistant to H2O2 (0–2mM) induced apoptosis. This anti-apoptotic effect may be mediated by the upregulation of Bcl-2, an anti-apoptotic protein through the activation pro-survival pathway extracellular signal regulated kinase (ERK). Through this mechanism, HCMV is able to propagate and causes endothelial dysfunction, hence vascular disease.
- Subjects
APOPTOSIS; HYDROGEN peroxide; DEATH (Biology); PATHOLOGY
- Publication
FEBS Letters, 2006, Vol 580, Issue 11, p2779
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2006.04.041