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- Title
<sup>31</sup>P RINEPT MRSI and VBM reveal alterations in brain aging associated with major depression.
- Authors
Biedermann, Sarah V.; Weber‐Fahr, Wolfgang; Demirakca, Traute; Tunc‐Skarka, Nuran; Hoerst, Mareen; Henn, Fritz; Sartorius, Alexander; Ende, Gabriele
- Abstract
Purpose Phosphomono- and diesters, the major components of the choline peak in 1H magnetic resonance spectroscopy, are associated with membrane anabolic and catabolic mechanisms. With the refocused insensitive nuclei-enhanced polarization transfer technique, these phospholipids are edited and enhanced in the 31P MR spectrum. In depressed patients, alterations of the choline peak and cerebral volume have been found, indicating a possible relation. Thus, combining MR phosphorous spectroscopy and volumetry in depressed patients seems to be a promising approach to detect underlying pathomechanisms. Methods Depressed in-patients were either treated with antidepressive medication or with electroconvulsive therapy and compared to matched healthy controls. 31P magnetic resonance spectroscopy imaging was conducted before and after the treatment phases. A 3D MRI dataset for volumetry was acquired in a dedicated 1H head coil. Results Phosphocholine and phosphoethanolamine were increased in depressed patients. Though patients responded to the treatments, phospholipids were not significantly altered. An increased age-related gray matter loss in fronto-limbic regions along with an altered relation of phosphomonoesters/phosphodiesters with age were found in depressed patients. Discussion The findings of increased phosphomonoesthers and an age*group interaction for gray matter volumes need further research to define the role of phospholipids in major depression and possible associations to gray matter loss. Magn Reson Med 73:1390-1400, 2015. © 2014 Wiley Periodicals, Inc.
- Publication
Magnetic Resonance in Medicine, 2015, Vol 73, Issue 4, pspcone
- ISSN
0740-3194
- Publication type
Other
- DOI
10.1002/mrm.25707