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- Title
Simultaneous single-quantum and triple-quantum-filtered MRI of 23Na (SISTINA).
- Authors
Fiege, Daniel P.; Romanzetti, Sandro; Mirkes, Christian C.; BrENner, Daniel; Shah, N. Jon
- Abstract
The low MR sensitivity of the sodium nucleus and its low concentration in the human body constrain acquisition time. The use of both single-quantum and triple-quantum sodium imaging is, therefore, restricted. In this work, we present a novel MRI sequence that interleaves an ultra-short echo time radial projection readout into the three-pulse triple-quantum preparation. This allows for simultaneous acquisition of tissue sodium concentration weighted as well as triple-quantum filtered images. Performance of the sequence is shown on phantoms. The method is demonstrated on six healthy informed volunteers and is applied to three cases of brain tumors. A comparison with images from tumor specific O-(2-[18F]fluoroethyl)- L-tyrosine positron emission tomography and standard MR images is presented. The combined information of the triple-quantum-filtered images with single-quantum images may enable a better understanding of tissue viability. Future studies can benefit from the evaluation of both contrasts with shortened acquisition times. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
- Publication
Magnetic Resonance in Medicine, 2013, Vol 69, Issue 6, p1691
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.24417