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- Title
Regional Variations of T<sub>2</sub>* in Healthy and Pathologic Achilles Tendon In Vivo at 7 Tesla: Preliminary Results.
- Authors
Juras, Vladimir; Zbyn, Stefan; Pressl, Christina; Valkovic, Ladislav; Szomolanyi, Pavol; Frollo, Ivan; Trattnig, Siegfried
- Abstract
The aim of this study was to investigate T2* in the Achilles tendon (AT), in vivo, using a three-dimensional ultrashort time echo (3DUTE) sequence, to compare field strength differences (3 and 7 T) and to evaluate a regional variation of T2* in healthy and pathologic tendon. Ten volunteers with no history of pain in the AT and five patients with chronic Achilles tendinopathy were recruited. 3D-UTE images were measured with the following echo times, at echo time 5 [0.07, 0.2, 0.33, 0.46, 0.59, 0.74, 1.0, 1.5, 2.0, 4.0, 6.0, and 9.0 ms]. T2* values in the AT were calculated by fitting the signal decay to biexponential function. Comparing volunteers between 3 and 7 T, short component T2s* was 0.71 ± 0.17 ms and 0.34 ± 0.09 ms (P < 0.05); bulk long component T2l* was 12.85 ± 1.87 ms and 10.28 ± 2.28 ms (P < 0.05). In patients at 7 T, bulk T2s* was 0.53 ± 0.17 ms (P = 0.045, compared to volunteers), T2l* was 11.49 ± 4.28 ms (P = 0.99, compared to volunteers). The results of this study suggest that the regional variability of AT can be quantified by T2* in in vivo conditions. Advanced quantitative imaging of the human AT using a 3D-UTE sequence may provide additional information to standard clinical imaging. Finally, as the preliminary patient data suggest, T2s* may be a promising marker for the diagnosis of pathological changes in the AT.
- Publication
Magnetic Resonance in Medicine, 2012, Vol 68, Issue 5, p1607
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.24136