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- Title
Phosphate wasting disorders in adults.
- Authors
Marcucci, G.; Masi, L.; Ferrarì, S.; Haffner, D.; Javaid, M.K.; Kamenický, P.; Reginster, J.-Y.; Rizzoli, R.; Brandi, M.L.
- Abstract
A cause of hypophosphatemia is phosphate wasting disorders. Knowledge concerning mechanisms involved in phosphate wasting disorders has greatly increased in the last decade by the identification of phosphatonins, among them FGF-23. FGF-23 is a primarily bone derived factor decreasing renal tubular reabsorption of phosphate and the synthesis of calcitriol. Currently, pharmacological treatment of these disorders offers limited efficacy and is potentially associated to gastrointestinal, renal, and parathyroid complications; therefore, efforts have been directed toward newer pharmacological strategies that target the FGF-23 pathway. This review focuses on phosphate metabolism, its main regulators, and phosphate wasting disorders in adults, highlighting the main issues related to diagnosis and current and new potential treatments.
- Subjects
KIDNEY tubules; RICKETS treatment; OSTEOMALACIA; PHOSPHATE metabolism; BONE regeneration; GROWTH factors; HYPOPHOSPHATEMIA; CALCITRIOL; ADULTS; THERAPEUTICS; PHYSIOLOGY
- Publication
Osteoporosis International, 2018, Vol 29, Issue 11, p2369
- ISSN
0937-941X
- Publication type
Article
- DOI
10.1007/s00198-018-4618-2