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- Title
Functionality‐Directed Regio‐ and Enantio‐Selective Olefinic C−H Functionalization of Aryl Alkenes.
- Authors
Zhu, Yuhang; Liao, Yilei; Jin, Shuqi; Ding, Liyuan; Zhong, Guofu; Zhang, Jian
- Abstract
Aryl alkenes represents one of the most widely occurring structural motif in countless drugs and natural products, and direct C−H functionalization of aryl alkenes provides atom‐ step efficient access toward valuable analogues. Among them, group‐directed selective olefinic α‐ and β‐C−H functionalization, bearing a directing group on the aromatic ring, has attracted remarkable attentions, including alkynylation, alkenylation, amino‐carbonylation, cyanation, domino cyclization and so on. These transformations proceed by endo‐ and exo−C−H cyclometallation and provide aryl alkene derivatives in excellent site‐ stereo‐selectivity. Enantio‐selective α‐ and β‐ olefinic C−H functionalization were also covered to synthesis axially chiral styrenes.
- Subjects
ALKENES; ALKENE derivatives; GROUP rings; NATURAL products; ALKENYLATION
- Publication
Chemical Record, 2023, Vol 23, Issue 5, p1
- ISSN
1527-8999
- Publication type
Article
- DOI
10.1002/tcr.202300012