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- Title
Multiplexing Quadrupole and Ion Trap Operation Modes on a "Brick" Miniature Mass Spectrometer.
- Authors
Feng, Chaohong; Liu, Siyu; Jiang, Ting; Xu, Wei
- Abstract
Although a quadruple mass analyzer and an ion trap mass analyzer have complementary analytical features, they usually have different geometries, operational modes, and electronic control systems. As a continuous effort to extend its coverage, both quadrupole and ion trap operation modes were realized on a "brick" miniature mass spectrometer with a single mass analyzer. In the quadrupole operation mode, low-mass ions ranging from 31 to 502 Th can be analyzed. On the other hand, the ion trap mode can be utilized to cover ions with higher mass to charge ratios (up to 922 Th), as well as performing tandem mass spectrometry. To realize the multiplexing of both operation modes, a printed circuit board (PCB)-based multi-electrode quadrupole–ion trap mass analyzer was designed and integrated in the system. To cover both volatile and non-volatile molecules, two ionization sources were also implemented, including a nano electrospray ionization source and an in-vacuum plasma ionization source. Performances of the instrument operated in these two modes were characterized, such as mass resolution, sensitivity, and mass range. Results demonstrate that the combination of the quadrupole and ion trap operation modes can provide new capabilities when solving analytical problems.
- Subjects
QUADRUPOLE mass analyzers; ION traps; MASS spectrometers; QUADRUPOLES; PRINTED circuits; PLASMA sources; ELECTROSPRAY ionization mass spectrometry
- Publication
Molecules, 2023, Vol 28, Issue 22, p7640
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28227640