We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Recent Synthetic Advances on the Use of Diazo Compounds Catalyzed by Metalloporphyrins.
- Authors
Simões, Mário M. Q.; Cavaleiro, José A. S.; Ferreira, Vitor F.
- Abstract
Diazo compounds are organic substances that are often used as precursors in organic synthesis like cyclization reactions, olefinations, cyclopropanations, cyclopropenations, rearrangements, and carbene or metallocarbene insertions into C−H, N−H, O−H, S−H, and Si−H bonds. Typically, reactions from diazo compounds are catalyzed by transition metals with various ligands that modulate the capacity and selectivity of the catalyst. These ligands can modify and enhance chemoselectivity in the substrate, regioselectivity and enantioselectivity by reflecting these preferences in the products. Porphyrins have been used as catalysts in several important reactions for organic synthesis and also in several medicinal applications. In the chemistry of diazo compounds, porphyrins are very efficient as catalysts when complexed with low-cost metals (e.g., Fe and Co) and, therefore, in recent years, this has been the subject of significant research. This review will summarize the advances in the studies involving the field of diazo compounds catalyzed by metalloporphyrins (M−Porph, M = Fe, Ru, Os, Co, Rh, Ir) in the last five years to provide a clear overview and possible opportunities for future applications. Also, at the end of this review, the properties of artificial metalloenzymes and hemoproteins as biocatalysts for a broad range of applications, namely those concerning carbene-transfer reactions, will be considered.
- Subjects
DIAZO compounds; METALLOPORPHYRINS; ORGANIC compounds; CATALYST selectivity; ORGANIC synthesis; TRANSITION metals; HEMOPROTEINS
- Publication
Molecules, 2023, Vol 28, Issue 18, p6683
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28186683