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- Title
Spiro-Flavonoids in Nature: A Critical Review of Structural Diversity and Bioactivity.
- Authors
Pecio, Łukasz; Pecio, Solomiia; Mroczek, Tomasz; Oleszek, Wiesław
- Abstract
Based on the literature data from 1973 to 2022, this work summarizes reports on spiro-flavonoids with a spiro-carbon at the center of their structure and how this affects their isolation methods, stereochemistry, and biological activity. The review collects 65 unique structures, including spiro-biflavonoids, spiro-triflavonoids, spiro-tetraflavonoids, spiro-flavostilbenoids, and scillascillin-type homoisoflavonoids. Scillascillin-type homoisoflavonoids comprise spiro[bicyclo[4.2.0]octane-7,3′-chromane]-1(6),2,4-trien-4′-one, while the other spiro-flavonoids contain either 2H,2′H-3,3′-spirobi[benzofuran]-2-one or 2′H,3H-2,3′-spirobi[benzofuran]-3-one in the core of their structures. Spiro-flavonoids have been described in more than 40 species of eight families, including Asparagaceae, Cistaceae, Cupressaceae, Fabaceae, Pentaphylacaceae, Pinaceae, Thymelaeaceae, and Vitaceae. The possible biosynthetic pathways for each group of spiro-flavonoids are summarized in detail. Anti-inflammatory and anticancer activities are the most important biological activities of spiro-flavonoids, both in vitro and in vivo. Our work identifies the most promising natural sources, the existing challenges in assigning the stereochemistry of these compounds, and future research perspectives.
- Subjects
STEREOCHEMISTRY; PINACEAE; BENZOFURAN; THYMELAEACEAE; CUPRESSACEAE; ANTI-inflammatory agents; FLAVONOIDS
- Publication
Molecules, 2023, Vol 28, Issue 14, p5420
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28145420