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- Title
Anticancer Inhibitors.
- Authors
Ammazzalorso, Alessandra; Fantacuzzi, Marialuigia
- Abstract
In the last years, CDK4/6 inhibitors revealed a therapeutic role for the treatment of breast cancer. Cancer is a multifactorial disorder caused by several aberrations in gene expression that generate a homeostatic imbalance between cell division and death. Structural modifications of the three FDA-approved CDK4/6 inhibitors furnished novel molecules currently under clinical investigation as antitumor drugs. Phosphatidylinositide-3-kinase (PI3K)/Akt signaling pathway inhibitors have undergone pre-clinical evaluation as a promising therapy for cancer treatment; the combination use of LY294002 and tamoxifen in breast cancer MCF-7 cells was indagated by Abdallah and coworkers.
- Subjects
DNA topoisomerase I; SAPONINS; ANTIBODY-directed enzyme prodrug therapy; NICOTINAMIDE; BIOSYNTHESIS
- Publication
Molecules, 2022, Vol 27, Issue 14, pN.PAG
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27144650