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- Title
Malondialdehyde-Modified LDL IgG Antibody Levels and Indices of Cardiac Function in Valvular Heart and Coronary Artery Disease Patients.
- Authors
Rahsepar, amir ali; Mirzaee, asadollah; Moodi, Fatemeh; Moohebati, Mohsen; Tavallaie, Shima; Khorashadizadeh, Fatemeh; Mottahedi, Behrooz; Esfehanizadeh, Jamil; azari, ali; Khojasteh, Roshanak; Mousavi, Somayeh; Paydar, Roghayeh; amini, Maral; Ghayour-Mobarhan, Majid; Ferns, Gordon a.; Sahebkar, amirhossein
- Abstract
Objective: To compare the changes in anti-malondialdehyde-modified low-density lipoprotein (MDA-LDL) IgG levels among patients undergoing off-pump and on-pump coronary artery bypass grafting (CABG) or valvuloplasty. Subjects and Methods: A total of 38, 39 and 34 patients who underwent off-pump CABG, on-pump CABG and valvuloplasty, respectively, were enrolled in this study. Serum anti-MDA-LDL IgG values were measured 24 h before and after the operative procedures and at discharge. Echocardiography was also done before surgery and before discharge. The results were compared with values from 50 healthy controls. Results: In all patients, a reduction in antibody titers was observed post-operatively. However, the decrease was significant only in the off-pump CABG - before surgery: 42.33 (25.83-58.51), after surgery: 30.86 (16.36-51.33) and at discharge: 10.96 (6.82-23.57; p = 0.027). There was a significant positive association between anti-MDA-LDL IgG levels and ejection fraction (r = 0.248, p = 0.036) and a negative association with E/E', a marker of pulmonary capillary wedge pressure, in the coronary patients (r = -0.345, p = 0.012), but no significant associations were found in patients with valvular heart disease. Conclusions: Serum anti-MDA-LDL IgG levels were associated with cardiac function indices in coronary patients undergoing CABG. © 2015 S. Karger AG, Basel
- Subjects
MALONDIALDEHYDE; LOW density lipoproteins; HEART valve diseases; CORONARY disease; IMMUNOGLOBULIN G; TRANSPLANTATION of organs, tissues, etc.
- Publication
Medical Principles & Practice, 2015, Vol 24, Issue 5, p424
- ISSN
1011-7571
- Publication type
Article
- DOI
10.1159/000431178