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- Title
H-2 Antigens on a murine lymphoma are associated with additional proteins.
- Authors
CALLAHAN, G. N.; ALLISON, J. P.
- Abstract
THERE have been reports indicating that the normal phenotypic expression of histocompatibility antigens is altered on tumour cells1, and a disappearance or diminution of H-2 expression on murine tumour cells has been demonstrated2,3. The nature of these changes has so far remained unclear. It has also been shown that H-2D and H-2K antigens are important in T-cell mediated lysis of virus infected or transformed syngeneic cells4,5. One explanation for these phenomena proposes that H-2 antigens are modified by association with additional cell-surface molecules to form a neoantigen or 'altered self'6. We report here immunochemical evidence for alteration of H-2 antigens on tumour cells by association with additional proteins.
- Publication
Nature, 1978, Vol 271, Issue 5641, p165
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/271165a0