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- Title
Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan.
- Authors
LI-HSIOU CHEN; KUO-LIANG CHIU; TE-CHUN HSIA; YEN-HSIEN LEE; TE-CHUN SHEN; CHIA-HSIANG LI; YI-CHENG SHEN; WEN-SHIN CHANG; CHIA-WEN TSAI; DA-TIAN BAU
- Abstract
Background/Aim: Matrix metalloproteinase 2 (MMP2) is reported to be overexpressed in asthma; however, its genotypic contribution to asthma is not well studied. Therefore, we examined the association of MMP2 genotypes with asthma risk among Taiwanese. Materials and Methods: One hundred and ninety-eight asthma patients and 453 nonasthmatic subjects were determined with respect to their MMP2 -1306 (rs243845) and -735 (rs2285053) genotypes. Results: CT and TT at MMP2 rs243845 are 17.7% and 1.5% among asthma cases, whereas their presence in healthy subjects is at 28.1% and 2.4%, respectively (p for trend=0.0118). In detail, the CT genotype in MMP2 rs243845 was associated with a decreased asthma risk [adjusted odds ratio (OR)=0.57, 95% confidence interval (CI)=0.37-0.78, p=0.0040], and the T allele conferred a significantly lower asthma risk compared to the wild-type C allele (adjusted OR=0.55, 95%CI=0.43-0.77, p=0.0042). No significance was found for MMP2 rs2285053. Conclusion: The genotype of CT in MMP2 rs243845 may serve as a novel biomarker in determining susceptibility to asthma in Taiwan.
- Subjects
TAIWAN; MATRIX metalloproteinases; PROMOTERS (Genetics); GENETICS of asthma; ASTHMA risk factors; GENOTYPES; DISEASE susceptibility; BIOMARKERS
- Publication
In Vivo, 2020, Vol 34, Issue 6, p3181
- ISSN
0258-851X
- Publication type
Article
- DOI
10.21873/invivo.12153