We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The re-emergence of natural products for drug discovery in the genomics era.
- Authors
Harvey, Alan L.; Edrada-Ebel, RuAngelie; Quinn, Ronald J.
- Abstract
Natural products have been a rich source of compounds for drug discovery. However, their use has diminished in the past two decades, in part because of technical barriers to screening natural products in high-throughput assays against molecular targets. Here, we review strategies for natural product screening that harness the recent technical advances that have reduced these barriers. We also assess the use of genomic and metabolomic approaches to augment traditional methods of studying natural products, and highlight recent examples of natural products in antimicrobial drug discovery and as inhibitors of protein-protein interactions. The growing appreciation of functional assays and phenotypic screens may further contribute to a revival of interest in natural products for drug discovery.
- Subjects
NATURAL products; DRUG development; TECHNOLOGICAL innovations; ANTI-infective agents; GENOMICS; METABOLOMICS
- Publication
Nature Reviews Drug Discovery, 2015, Vol 14, Issue 2, p111
- ISSN
1474-1776
- Publication type
Article
- DOI
10.1038/nrd4510