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- Title
VALIDATED STABILITY INDICATING SPECTROSCOPIC METHOD FOR ESTIMATION OF DEGRADATION BEHAVIOUR OF VALSARTAN AND HYDROCHLOROTHIAZIDE IN TABLET FORMULATION.
- Authors
Kalyankar, Tukaram M.; Dange, Shital S.; Hambarde, Shivraj B.; Wadher, Shailesh J.; Shete, Shivkumar K.
- Abstract
A simple, accurate and precise UV spectrometric method has been developed for the simultaneous determination of valsartan and hydrochlorothiazide in tablet dosage form. Spectra of valsartan and hydrochlorothiazide in methanol and water (50:50 V/V) show λ max at 250.0 nm and 271.4 nm, respectively. Valsartan and hydrochlorothiazide are subjected to various stress conditions like acid, alkali, thermal and photolytic degradation. Beer's law was obeyed in concentration range of 4-24 μg mL-1 for valsartan and 0.5-3 μg mL-1 for hydrochlorothiazide at their respective wavelengths. The proposed method was successfully applied to tablet dosage form for determination of both drugs. The percentage recovery of valsartan and hydrochlorothiazide were found to be 100.19 % and 99.51 %, respectively. A novel accurate and precise stability indicating spectroscopic method has been developed for estimation of valsartan and hydrochlorothiazide.
- Subjects
HYDROCHLOROTHIAZIDE; BEER-Lambert law; VALSARTAN
- Publication
Indian Drugs, 2021, Vol 58, Issue 11, p53
- ISSN
0019-462X
- Publication type
Article
- DOI
10.53879/id.58.11.11285