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- Title
Positive Association of Urinary Dimethylarsinic Acid (DMA V) with Serum 25(OH)D in Adults Living in an Area of Water-Borne Arsenicosis in Shanxi, China.
- Authors
Zhang, Kunyu; Yin, Yunyi; Lv, Man; Zhang, Xin; Zhang, Meichen; Cui, Jia; Guan, Ziqiao; Liu, Xiaona; Liu, Yang; Gao, Yanhui; Yang, Yanmei
- Abstract
Limited studies have demonstrated that inorganic arsenic exposure is positively associated with serum vitamin D levels, although the correlation between urinary arsenic species and serum vitamin D has not been investigated in areas of water-borne arsenicosis. A cross-sectional study of 762 participants was conducted in Wenshui Country, Shanxi Province, a water-borne arsenicosis area. The results showed a positive relationship between urinary arsenic species (inorganic arsenic (iAs), methylarsonic acid (MMAV), dimethylarsinic acid (DMAV) and serum 25(OH)D. Log-binomial regression analysis indicated a 0.4% increase in the risk of vitamin D excess for every 1-unit increment in the Box–Cox transformed urinary DMAV after adjustment for covariates. After stratifying populations by inorganic arsenic methylation metabolic capacity, serum 25(OH)D levels in the populations with iAs% above the median and primary methylation index (PMI) below the median increased by 0.064 ng/mL (95% CI: 0.032 to 0.096) for every one-unit increase in the Box–Cox transformed total arsenic (tAs) levels. Serum 25(OH)D levels increased by 0.592 ng/mL (95% CI: 0.041 to 1.143) for every one-unit rise in the Box–Cox transformed iAs levels in people with skin hyperkeratosis. Overall, our findings support a positive relationship between urinary arsenic species and serum 25(OH)D. It was recommended that those residing in regions with water-borne arsenicosis should take moderate vitamin D supplements to avoid vitamin D poisoning.
- Subjects
SHANXI Sheng (China); CACODYLIC acid; DIETARY supplements; ADULTS; ARSENIC; BONE density; REGRESSION analysis; VITAMIN D
- Publication
Toxics, 2024, Vol 12, Issue 1, p83
- ISSN
2305-6304
- Publication type
Article
- DOI
10.3390/toxics12010083