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- Title
Transient distal renal tubular acidosis with nephrogenic diabetes insipidus after general anaesthesia in a dog.
- Authors
Ku, Dayoung; Lee, Dohee; Yun, Taesik; Koo, Yoonhoi; Chae, Yeon; Choi, Dongjoon; Choi, Minseok; Kang, Byeong‐Teck; Yang, Mhan‐Pyo; Kim, Hakhyun
- Abstract
A 3‐year‐old, 3.5 kg, female spayed Pomeranian was referred due to persistent vomiting, anorexia, polyuria and polydipsia, 7 days after receiving general anaesthetic for a medial patellar luxation correction. Physical examination revealed lethargy, tachypnoea and 7% dehydration. Complete blood count and serum chemistry results were unremarkable, and venous blood gas analysis revealed hypokalaemia and hyperchloraemic metabolic acidosis with a normal anion gap. Urinalysis revealed a urine specific gravity (USG) of 1.005, pH of 7.0 and proteinuria, and the bacterial culture was negative. Based on these results, the dog was diagnosed with distal renal tubular acidosis, and potassium citrate was prescribed to correct metabolic acidosis. In addition, concurrent diabetes insipidus (DI) was suspected because the dog showed persistent polyuria, polydipsia and a USG below 1.006 despite dehydration. After 3 days of initial treatment, acidosis was corrected, and vomiting resolved. Desmopressin acetate and hydrochlorothiazide were also prescribed for DI, but the USG was not normalized. Based on the insignificant therapeutic response, nephrogenic DI was highly suspected. DI was resolved after 24 days. This case report describes the concomitant presence of RTA and DI in a dog after general anaesthesia. The manuscript describes a clinical case of both transient distal renal tubular acidosis and nephrogenic diabetes insipidus in a dog showing repetitive vomiting after general anaesthesia. The aetiology of repetitive vomiting was a compensatory mechanism for metabolic acidosis caused by distal renal tubular acidosis. The clinical course and diagnostic approach for transient distal renal tubular acidosis with concurrent nephrogenic diabetes insipidus are described. Furthermore, suspected mechanisms for this clinical sequelae are discussed.
- Subjects
DIABETES insipidus; RENAL tubular transport disorders; ACIDOSIS; BLOOD cell count; PATELLA dislocation; SPECIFIC gravity; ANESTHESIA
- Publication
Veterinary Medicine & Science, 2023, Vol 9, Issue 4, p1483
- ISSN
2053-1095
- Publication type
Article
- DOI
10.1002/vms3.1165