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- Title
Effect of synbiotics in the treatment of smokers and non-smokers with gingivitis: randomized controlled trial.
- Authors
Ercan, N; Olgun, E; Kisa, Ü; Yalim, M
- Abstract
<bold>Background: </bold>To evaluate the efficacy of synbiotic tablets on the clinical and biochemical parameters of smokers and non-smokers with gingivitis.<bold>Methods: </bold>Eighty patients with gingivitis [40 smokers (+), 40 non-smokers (-)] were randomly assigned to test (T) or control (C) groups. Four groups were defined: T(+), T(-), C(+) and C(-). The subjects daily chewed a synbiotic or placebo tablet for 30 days. The gingival crevicular fluid levels of interleukin (IL)-6, IL-8 and IL-10 were determined as the primary outcome variables.<bold>Results: </bold>The clinical and biochemical parameters for all groups significantly reduced compared with the baseline (P < 0.05). While there were no significant differences between the groups for gingival index, the plaque index was significantly higher in both smoker groups than that in the T(-) group during the second month (P < 0.05). IL-8 levels in C(-) and IL-6 levels in both control groups were significantly higher than those in the T(+) group. The IL-10 levels in both control groups were significantly higher than those in the T(-) group during the second month (P < 0.05).<bold>Conclusions: </bold>Adjunctive synbiotic tablets significantly reduce subclinical therapeutic outcomes for both smokers and non-smokers compared with placebo according to the biochemical parameters.
- Subjects
RANDOMIZED controlled trials; TREATMENT effectiveness; GINGIVITIS; NICOTINE replacement therapy; GINGIVAL fluid; GINGIVAL grafts; PLACEBOS; RESEARCH; RESEARCH methodology; EVALUATION research; MEDICAL cooperation; DIETARY supplements; COMPARATIVE studies; EXUDATES &; transudates; RESEARCH funding; SMOKING
- Publication
Australian Dental Journal, 2020, Vol 65, Issue 3, p210
- ISSN
0045-0421
- Publication type
journal article
- DOI
10.1111/adj.12755