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- Title
Dietary Tocopherol Supplementation after Trabeculectomy and Phacotrabeculectomy: Double-Blind Randomized Placebo-Controlled Trial.
- Authors
David Goldblum; Alexander Meyenberg; Daniel Mojon; Christoph Tappeiner; Beatrice E. Frueh
- Abstract
Purpose: The vitamin E compound α-tocopherol inhibits fibroblast growth in vitro. To evaluate its potential benefit in preventing failure of glaucoma filtration surgery, we prospectively investigated the outcome of filtering surgery with postoperative dietary α-tocopherol supplementation. Patients and Methods: Thirty-nine patients (39 eyes) with primary open-angle glaucoma or pseudoexfoliative glaucoma were randomly assigned to two post-(phaco)-trabeculectomy treatment groups. Daily oral intake of 300 mg α-tocopheryl-acetate (absorbed as α-tocopherol in the intestine) for 2 months was compared to a placebo preparation in a double-blind trial. The follow-up time was 1 year. Success was defined as intraocular pressure (IOP) ≤18 mm Hg with no medication, no needling revision, and no subconjunctival injection. Results: In the tocopherol group, the relative risk for trabeculectomy failure decreased from 1.58 at 2 weeks (p = 0.95) to 1.0 at 1 year. Success rates (67–90) and IOP reduction (mean 39 to 53) were statistically comparable in the two groups. Considering postoperative complications, no relevant differences were found. Discussion: Trabeculectomy and phacotrabeculectomy outcome did not show any differences between α-tocopherol-supplemented patients and the placebo group.
- Subjects
SURGICAL nutrition; GLAUCOMA surgery; DIETARY supplements; VITAMIN E; VITAMINS in human nutrition; INTRAOCULAR pressure; HEALTH outcome assessment; RANDOMIZED controlled trials
- Publication
Ophthalmologica, 2009, Vol 223, Issue 4, p226
- ISSN
0030-3755
- Publication type
Article
- DOI
10.1159/000203367