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- Title
Oxidized lipids: not just another brick in the wall1.
- Authors
Stamenkovic, Aleksandra; Pierce, Grant N.; Ravandi, Amir
- Abstract
Over the past decade, there has been intense investigation in trying to understand the pathological role that oxidized phospholipids play in cardiovascular disease. Phospholipids are targets for oxidation, particularly during conditions of excess free radical generation. Once oxidized, they acquire novel roles uncharacteristic of their precursors. Oxidized phosphatidylcholines have an important role in multiple physiological and pathophysiological conditions including atherosclerosis, neurodegenerative diseases, lung disease, inflammation, and chronic alcohol consumption. Circulating oxidized phosphatidylcholine may also serve as a clinical biomarker. The focus of this review, therefore, will be to summarize existing evidence that oxidized phosphatidylcholine molecules play an important role in cardiovascular pathology.
- Subjects
PHOSPHOLIPIDS; CARDIOVASCULAR diseases; OXIDATION; ATHEROSCLEROSIS; NEURODEGENERATION
- Publication
Canadian Journal of Physiology & Pharmacology, 2019, Vol 97, Issue 6, p473
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2018-0490