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- Title
Neonatal intestinal injury induced by maternal separation: pathogenesis and pharmacological targets1.
- Authors
Li, Bo; Yu, Fang Zhou; Minich, Adam; Hock, Alison; Lee, Carol; Pierro, Agostino
- Abstract
Maternal separation (MS) is a well-studied phenomenon thought to play a role in the pathogenesis of many diseases ranging from neuropsychiatric to early intestinal disorders such as necrotizing enterocolitis. The existing evidence suggests that MS initiates a variety of processes that in turn lead to early intestinal injury. Although there are many theories as to how MS alters normal physiological processes, the exact mechanism of action remains to be elucidated. This review aims to describe some of the pathological processes affecting the intestine that are caused by MS, including (i) brain–gut axis, (ii) intestinal epithelial barrier function, (iii) microbiome, (iv) oxidative stress and endoplasmic reticulum stress, and (v) gut inflammation.
- Subjects
INTESTINAL injuries; NEONATAL diseases; INFLAMMATION; HUMAN microbiota; OXIDATIVE stress; ENDOPLASMIC reticulum; NEONATAL necrotizing enterocolitis
- Publication
Canadian Journal of Physiology & Pharmacology, 2019, Vol 97, Issue 3, p193
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2018-0370