We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Can neurocognition, brain neurotrophic factor, triglyceride, and total cholesterol predict suicidal ideation in first‐episode Han Chinese patients with schizophrenia?
- Authors
Dongxia, Li; Li, Ma; Yingying, Feng
- Abstract
Objective: Previous studies have suggested that the suicide rate of patients with schizophrenia is high. This study investigates factors influencing suicidal ideation in first‐episode schizophrenia patients, focusing on cognitive function, brain‐derived neurotrophic factor (BDNF), triglyceride (TG), and total cholesterol (TC) in patients with first‐episode schizophrenia. Methods: A total of 123 patients with first‐episode schizophrenia and 38 healthy controls were included in the study. The patients were divided into suicidal and nonsuicidal ideation groups based on the Beck Scale for Suicidal Ideation, and they were assessed with Positive and Negative Syndrome Scale (PANSS). Cognitive function was assessed using the Chinese version of the MATRICS consensus cognitive battery (MCCB) and the serum BDNF, TG, and TC were detected. The main statistical methods include t‐test, χ2 test, multivariate logistic regression analysis, receiver operating characteristic (ROC) curve analysis, and the DeLong test. Results: 26.02% of patients exhibited suicidal ideation. Higher PANSS and TC levels were risk factors, while higher MCCB scores and BDNF levels were protective factors. ROC analysis indicated AUCs of 0.630, 0.724, and 0.762 for serum BDNF, PANSS, and MCCB, respectively, with a combined AUC of 0.870. Conclusion: Serum BDNF level, PANSS score, and MCCB score can be used as auxiliary predictors of suicidal ideation in schizophrenic patients. Combining these three indicators can effectively predict suicidal ideation in schizophrenic patients.
- Subjects
SUICIDAL ideation; CHINESE people; PEOPLE with schizophrenia; BRAIN-derived neurotrophic factor; RECEIVER operating characteristic curves; PITUITARY adenylate cyclase activating polypeptide; RISPERIDONE; HYDROXYCHOLESTEROLS
- Publication
Brain & Behavior, 2024, Vol 14, Issue 5, p1
- ISSN
2162-3279
- Publication type
Article
- DOI
10.1002/brb3.3499