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- Title
Prophylactic effects of Q10 capsule on proteinuria in diabetic patients.
- Authors
Sedeh, Bahman Sadeghi; Sadeghi, Sahar; Mohaghegh, Pegah; begi, Ali khosro; Mohamadi, Raziyeh; Sabzevari, Sima; Amiri, Parastoo; Goudarzian, Maryam
- Abstract
Diabetic nephropathy is the most common cause of end stage renal failure in the world. Rigid control of blood pressure and blood sugar is effective in preventing the onset and progression of the disease. But an effective method of preventing it has not yet been identified. Coenzyme Q10 is effective in controlling oxidative stress, glycemic control, and blood pressure. Therefore, its capacity for preventing diabetic nephropathy can be investigated. In this double blind randomized clinical trial, 68 eligible diabetic patients with normoalbuminuria or microalbuminuria were randomly selected and were divided to two mached groups of 34 by tossing coin. In both groups, fasting blood sugar, 2-hour post prandial glucose, HbA1C, albumin to urinary creatinine ratio (Alb/Cr), and diastolic and systolic blood pressure were measured. One group received 100 mg Q10 daily for 8 weeks and the other group received 8 weeks of placebo. Both groups were monitored and examained every 3 months and finally after 18 months, the variables were again measured by the same initial method and the results were compared with t-test and repeated mesure analysis. The Q10 capsule was able to significantly reduce fasting blood glucose, 2h post prandial glucose, HbA1C, and albumin / urinary creatinine ratio (proteinuria) (p≤0.05), but did not significantly change systolic and diastolic blood pressure. In this 18-month follow-up, Q10 showed prophylactic effects on glycemic control and proteinuria.
- Subjects
DIABETIC nephropathies; PROTEINURIA; UBIQUINONES; BLOOD pressure; GLYCEMIC control; DIABETES
- Publication
Revista Latinoamericana de Hipertension, 2018, Vol 13, Issue 3, p291
- ISSN
1856-4550
- Publication type
Article