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- Title
Study of pharmacokinetics of an in situ forming gel system for controlled delivery of florfenicol in pigs.
- Authors
Geng, Z.‐X.; Li, H.‐M.; Tian, J.; Liu, T.‐F.; Yu, Z.‐G.
- Abstract
To reduce florfenicol ( FFC) administration frequency in veterinary use, the drug was currently developed into in situ forming gel. Twelve pigs were randomly divided into two groups (six pigs per group). A single i.m. dose of 40 mg/kg body weight (b.w.) was given to pigs, group one was given FFC in situ forming gel, and group two was given FFC conventional injection. High-performance liquid chromatography ( HPLC) was used to determine FFC plasma concentrations. There were significant differences ( P < 0.01) between FFC in situ forming gel and conventional injection, in pharmacokinetic parameters MRT (mean retention time) (57.79 ± 2.88) h versus (15.94 ± 1.29) h, AUC (area under the concentration-time curve) (421.54 ± 8.97) μg·h/ mL versus (168.16 ± 4.59) μg·h/ mL, tmax (time of occurrence of cmax) (9.00 ± 2.68) h versus (4.33 ± 0.82) h, cmax (maximum plasma concentration) (6.87 ± 0.66) μg/mL versus (12.01 ± 0.66) μg/mL, t1/2 λz (terminal elimination half-life) (38.04 ± 2.20) h versus (9.15 ± 2.71) h. The results demonstrated that the in situ forming gel system could shorten dosing interval of FFC and thus achieved less frequent administration during long-term treatment.
- Subjects
PHARMACOKINETICS; VETERINARY medicine; THIAMPHENICOL; SWINE diseases; GRAM-negative bacterial diseases; PROTEIN synthesis
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2015, Vol 38, Issue 6, p596
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/jvp.12218