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- Title
Cyclosporin A induces a selective, reversible suppression of T-helper lymphocyte regeneration after syngeneic bone marrow transplantation: association with syngeneic graft-versus-host disease in rats.
- Authors
Bos, G. M. J.; Majoor, G. D.; van Breda Vriesman, P. J. C.
- Abstract
Experimental studies in rats have established that a combination of lethal X-irradiation, syngeneic bone marrow transplantation (sBMT) and temporary administration of Cyclosporin A (CyA) leads lo the development of a disease defined as syngeneic graft-versus-host disease or CyA-induced autoimmunity. This study demonstrates that the combination of lethal X-irradiation, sBMT, and CyA selectively suppresses the repopulation of T-helper cells, as monitored in peripheral blood. The suppression of T-helper cell regeneration is maintained as long as CyA is administered. In addition, development of CyA- induced autoimmunity does not start as long as CyA is given. After withdrawal of CyA T-helper cells recover. Their reappearance in the peripheral circulation coincides with the development of syngeneic graft-versus-host disease, suggesting a role of these cells in initiating or causing the disease.
- Subjects
IRRADIATION; BONE marrow; AUTOANTIBODIES; MURIDAE; AUTOIMMUNITY; PERIPHERAL circulation
- Publication
Clinical & Experimental Immunology, 1988, Vol 74, Issue 3, p443
- ISSN
0009-9104
- Publication type
Article