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- Title
Interleukin 6 (IL-6) in serum and urine of renal transplant recipients.
- Authors
Van Oers, M. H. J.; Van Der Heyden, A. A. P. A. M.; Aarden, L. A.
- Abstract
Hybridoma growth factor (HGF) Is a 20-25 kD protein, supporting the growth of hybridoma cells in vitro and capable of replacing feeder cells. It was shown to be produced by human monocytes and a number of cultured cell lines. Recently, HGF was found to be identical to interferon-β2 or 26 kD protein and BSF-2, and was renamed interleukin 6 (IL-6). Using a sensitive bio-assay we were able to measure IL-6 activity in the serum and urine of healthy volunteers and renal transplant recipients. Low levels of IL-6 were present in the serum but not in the urine of healthy individuals. In contrast, both serum and urine of renal transplant recipients contained high levels of IL-6 directly after transplantation and during acute rejection episodes. On the basis of kinetic studies of the IL-6 response, it is concluded that serial measurement of IL-6, especially in urine, may be of value in monitoring renal transplant recipients. Moreover, the sensitivity of the bioassay will allow for detailed studies as to the biological significance of IL-6 in health and disease.
- Subjects
INTERLEUKIN-6; KIDNEY transplantation; SERUM; URINE; MONOCYTES; CELL lines; PROTEINS; BIOLOGICAL assay
- Publication
Clinical & Experimental Immunology, 1988, Vol 71, Issue 2, p314
- ISSN
0009-9104
- Publication type
Article