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- Title
Specific proliferative response of human lymphocytes to purified soluble antigens from Plasmodium falciparum in vitro cultures and to antigens from malaria patients' sera.
- Authors
Bygbjerg, I.C.; Jepsen, S.; Theander, T.G.; Dum, N.
- Abstract
Antigens of Plasmodium fakiparum, in supernatant's of in vitro cultures of the parasite were affinity purified on columns prepared with the IgG fraction of the serum of an immune individual. The purified antigens induced proliferation of lymphocytes from persons who had recently had malaria. The responses were strongest with lymphocytes from individuals infected with falciparum and oval malaria; vivax malaria infections induced a lower level of response and lymphocytes of unsensitized individuals were little affected. Lymphocytes from unsensilized individuals did not respond to the affinity purified antigen preparations from malaria patients' sera indicating that significant amounts of non-specific mitogens were not present.
- Subjects
MALARIA; ANTIGENS; IMMUNITY; IMMUNOGLOBULINS; LEUCOCYTES; SERUM
- Publication
Clinical & Experimental Immunology, 1985, Vol 59, Issue 2, p421
- ISSN
0009-9104
- Publication type
Article