We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chronic myelocytic leukaemia: HLA association and decreased erythrocyte C3b receptor expression.
- Authors
Ruuska, P.; Silvennoinen-Kassinen, Sylvi; Timonen, T.; Tiilikainen, Anja
- Abstract
A series of 27 adult patients with chronic myelocytic leukaemia (CML) were examined for erythrocyte Cab receptor (EC3bR) expression. Twenty-five patients were successfully HLA typed and there was a positive association of CML with HLA-B40 (<001), Only 10 (37%) of the patients were EC3bR positive (< 0-000001) compared to 223 healthy controls of whom 198 (89%) were EC3bR positive. The positivity of EC3bR and HLA-B40 occurred simultaneously in six patients (<0-05), HLA-B40 positivity and EC3bR expression were correlated with the following variables; age at the time of CML diagnoses, duration of CML (until death or the end of follow-up period 1 July 1983), the stage of CML and simultaneous medication, EC3bR positive patients were significantly more often in remission (P< 0-05) and also had shorter duration ofthe disease (P < 0-005) then did EC3bR negative ones. No significant correlation existed between EC3bR status and the other parameters. The presence of HLA-B40 did not associate with any of the listed variables. These findings may indicate the loss of the receptor in the course of CML with increasing immaturity of cells released from bone marrow.
- Subjects
BONE marrow; MYELOID leukemia; IMMUNE system; ERYTHROCYTES; BLOOD group antigens; NONLYMPHOID leukemia
- Publication
Clinical & Experimental Immunology, 1985, Vol 59, Issue 2, p300
- ISSN
0009-9104
- Publication type
Article