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- Title
Antigenic competition between horse and sheep red blood cells as a hormone-dependent phenomenon.
- Authors
Besedovsky, H. O.; Del Rey, Adriana; Horkis, E.
- Abstract
Various mechanisms for understanding antipenie competition have been proposed, such as macrophage availability, suppressor cells and their soluble products. In view of the regulatory function of some hormones on the immune system, the role of immunosuppressive adrenal corticosteroids in antigenic competition was investigated. When horse red blood cells (HRBC) were injected into rats a five-fold increase in corticosterone blood levels was measured by day 6 and a strong decrease was noted on day 11. In animals injected with HRBC and on day 6 with a second antigen (sheep red blood cells, SRBC), the corticosteroid level was high on day 11. Such high levels are immunosuppressive. To impede such increases in adrenal hormone levels, rats were adrenalectomized. Adrenalectomized or sham-operated animals receiving SRBC only showed no difference in plaque-forming cell (PFC) numbers. All sham-operated rats injected first with IIRBC! and 5 days later with SRBC showed the expected antigenic competition. Adrenalectomized rats also injected with both antigetis sequentially had a five fold increase in number of PFC when compared with the sham-operated controls which had received both antigens. A detailed analysis of these data revealed that a proportion of adrenaiectomized animals had PFC numbers within the normal range. In vitro, hydrocortisone enhances the response of spleen cells when only one antigen (SRBC) is present. Prior addition of the unrelated antigen (SRBC) impedes this enhancement. Thus, in a hydroeortisone-enriched culture medium, the presence of the first antigen can interfere with the immune response to the second unrelated antigen, mimicking in vitro a condition of antigenic competition. These findings indicate that hormones may have a role in antigenic competition.
- Subjects
IMMUNE response; IMMUNE system; ERYTHROCYTES; BLOOD cells; CATECHOLAMINES; ADRENOCORTICAL hormones; IMMUNOLOGY
- Publication
Clinical & Experimental Immunology, 1979, Vol 37, Issue 1, p106
- ISSN
0009-9104
- Publication type
Article