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- Title
The tumor suppressor Pml regulates cell fate in the developing neocortex.
- Authors
Regad, Tarik; Bellodi, Cristian; Nicotera, Pierluigi; Salomoni, Paolo
- Abstract
The control of cell fate in neural progenitor cells is critical for nervous system development. Nevertheless, the processes involved are only partially known. We found that the expression of the tumor suppressor Pml was restricted to neural progenitor cells (NPCs) in the developing neocortex of the mouse. Notably, in Pml−/− cortices, the overall number of proliferating NPCs was increased and transition between the two major progenitor types, radial glial cells and basal progenitors, was impaired. This in turn resulted in reduced differentiation and an overall decrease in the thickness of the cortex wall. In NPCs, Pml regulated the subcellular distribution of the retinoblastoma protein (pRb) and the protein phosphatase 1α, triggering pRb dephosphorylation. Together, these findings reveal an unexpected role of Pml in controlling the function of NPCs in the CNS.
- Subjects
TUMOR suppressor genes; NEOCORTEX; CELL determination; NERVOUS system; CELL proliferation; RETINOBLASTOMA; NEUROGLIA; CEREBRAL cortex
- Publication
Nature Neuroscience, 2009, Vol 12, Issue 2, p132
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.2251